It鈥檚 one of the inescapable realities of aging: The older we get, the slower we tend to move鈥攚hether we鈥檙e walking around the block or just reaching for the remote control.
A new study led by CU听Boulder engineers helps explain why.
The research is one of the first studies to experimentally tease apart the competing reasons why people over age 65 might not be as quick on their feet as they used to be. The group reported that older adults may move slower, at least in part, because it costs them more energy than younger people鈥攑erhaps not too shocking for anyone who鈥檚 woken up tired the morning after an active day.
The findings could one day give doctors new tools for diagnosing a range of illnesses, including Parkinson鈥檚 disease, multiple sclerosis and even depression and schizophrenia, said study co-author Alaa Ahmed.听
鈥淲hy we move the way we do, from eye movements to reaching, walking and talking, is a window into aging and Parkinson鈥檚,鈥� said Ahmed, professor in the Paul M. Rady Department of Mechanical Engineering. 鈥淲e鈥檙e trying to understand the neural basis of that.鈥�
She and her colleagues in the journal JNeurosci.
Mary Kaupas participates in a experiment to study how humans of various ages reach for targets. Tubes monitor her breathing to measure how much energy she uses. (Credit: Erik Summerside/Mary Kaupas)
For the study, the group asked subjects age 18 to 35 and 66 to 87 to complete a deceptively simple task: to reach for a target on a screen, a bit like playing a video game on a Nintendo Wii. By analyzing patterns of these reaches, the researchers discovered that older adults seemed to modify their motions under certain circumstances to conserve their more limited supplies of energy.听
"All of us, whether young or old, are inherently driven to get the most reward out of our environment while minimizing the amount of effort to do so,鈥� said Erik Summerside, a co-lead author of the new study who earned his doctorate in integrative physiology from 蜜桃传媒破解版下载 in 2018.
Using engineering to understand the brain
Ahmed added that researchers have long known that older adults tend to be slower because their movements are less stable and accurate. But other factors could also play a role in this fundamental part of growing up.
According to one hypothesis, the muscles in older adults may work less efficiently, meaning that they burn more calories while completing the same tasks as younger adults鈥攍ike running a marathon or getting up to grab a soda from the refrigerator.
Alternatively, aging might also alter the reward circuitry in the human brain. Ahmed explained that as people age, their bodies produce less dopamine, a brain chemical responsible for giving you a sense of satisfaction after a job well done. If you don鈥檛 feel that reward as strongly, the thinking goes, you may be less likely to move to get it. People with Parkinson鈥檚 disease experience an even sharper decline in dopamine production.
In the study, the researchers asked more than 80 people to sit down and grab the handle of a robotic arm, which, in turn, operated the cursor on a computer screen. The subjects reached forward, moving the cursor toward a target. If they succeeded, they received a reward鈥攏ot a big one, but still enough to make their brains happy.
鈥淪ometimes, the targets exploded, and they would get point rewards,鈥� Ahmed said. 鈥淚t would also make a 鈥榖ing bing鈥� sound.鈥�
Moving slower but smarter
That鈥檚 when a contrast between the two groups of people began to emerge.
Both the 18 to 35-year-olds and 66 to 87-year-olds arrived at their targets sooner when they knew they would hear that bing bing鈥攔oughly 4% to 5% sooner over trials without the reward. But they also achieved that goal in different ways.
The younger adults, by and large, moved their arms faster toward the reward. The older adults, in contrast, mainly improved their reaction times, beginning their reaches about 17 milliseconds sooner on average.
When the team added an 8-pound weight to the robotic arm for the younger subjects, those differences vanished.
"The brain seems to be able to detect very small changes in how much energy the body is using and adjusts our movements accordingly,鈥� said Robert Courter, a co-lead author of the study who earned his doctorate in integrative physiology from 蜜桃传媒破解版下载 in 2023. 鈥淓ven when moving with just a few extra pounds, reacting quicker became the energetically cheaper option to get to the reward, so the young adults imitated the older adults and did just that.鈥�
The research seems to paint a clear picture, Ahmed said: Both the younger and older adults didn鈥檛 seem to have trouble perceiving rewards, even small ones. But their brains slowed down their movements under tiring circumstances.
鈥淧utting it all together, our results suggest that the effort costs of reaching seem to be determining what鈥檚 slowing the movement of older adults,鈥� Ahmed said.
The experiment can鈥檛 completely rule out the brain鈥檚 reward centers as a culprit behind why we slow down when we age. But, Ahmed noted, if scientists can tease out where and how these changes emerge from the body, they may be able to develop treatments to reduce the toll of aging and disease.
