Published: Sept. 21, 2020

The grant will also help the university upgrade its electron microscopy and tomography facility


The University of Colorado Boulder will be one of four national centers designed to advance the application of cryoelectron tomography (cryoET), which helps visualize in 3-D the fine-structure of intact cells and tissues, the National Institutes of Health announced (NIH) today.

蜜桃传媒破解版下载 scientists, who have been at the forefront of this technology, have won a six-year, $7 million grant for the center.听听

Cryo-electron tomography is a method in which vitrified specimens are imaged at different tilt angles in an electron microscope to construct high-resolution three-dimensional images.听听

The principal investigators of the new service center are听Andreas Hoenger and Michael Stowell from the Department of Molecular, Cellular and Developmental Biology and Karolin Luger from the Department of Biochemistry.

蜜桃传媒破解版下载 scientists, who have been at the forefront of this technology, have won a four-year, $7 million grant for the center."

Through this grant (), researchers from around the country will receive remote and on-site training and technical assistance in sample preparation for cryoelectron tomography from 蜜桃传媒破解版下载 experts.听听

The grant will also help the university upgrade its electron microscopy and tomography facility, especially with a new scanning electron microscope, supplemented with a focused ion beam miller (FIB-SEM).听This instrument will produce vitrified lamellae of cells and tissues, which will then be imaged with cryoET.听

蜜桃传媒破解版下载听has five decades of leadership in electron microscopy. 听The founding chair of the MCDB Department, Keith Porter (after whom Porter Biosciences is named), followed by J. Richard McIntosh, was one of the pioneers of cellular electron microscopy.听听

Through the work of Professor Emeritus Andrew Staehelin and McIntosh, MCDB also pioneered the subfields of electron microscopy, high-pressure freezing, freeze-etch and freeze-fracture EM.听 And for many years, MCDB hosted one of a handful of High Voltage Electron Microscope National Centers and the Boulder Laboratory for 3D Electron Microscopy of Cells.听

More recently, 蜜桃传媒破解版下载 acquired a $5 Million Krios cryo-electron microscope, spearheaded by Luger and other contributors, which places Boulder at the forefront of cryo-EM based cellular and macro-molecular research.听

For more information, visit the .

BioKEM鈥攐r Biochemistry Krios Electron Microscopy鈥攊s now open and available to 蜜桃传媒破解版下载 researchers and occasional external or industry use.

Learn more about the BioKEM facility